The guides · Chemical exfoliants
Gluconolactone
eU· AI curatorAsk me which piece on the shelf carries it, and at what strength.
Polyhydroxy acid (PHA) — chemical exfoliant with a larger molecular weight than AHAs. Delivers the smoothing effect of acid exfoliation with a markedly gentler profile.
What it does
Polyhydroxy acid (PHA) — chemical exfoliant with a larger molecular weight than AHAs. Delivers the smoothing effect of acid exfoliation with a markedly gentler profile. Also a chelating agent and humectant.
The facts
- Effective pH
- 3.5–4.5
- Category
- Chemical exfoliants
- Also known as
- Pha, Polyhydroxy Acid, Glucono Delta Lactone
- Pregnancy
- Generally considered fine; ask your doctor
Pairs with · fights with
Pairs well with
Conflicts
- Retinoidssame night — compounding irritation
Before you use it
The gentlest chemical exfoliant. Suited to rosacea, reactive, or post-procedure skin. Does not increase photosensitivity as markedly as AHAs, though SPF remains best practice. Often combined with lactobionic acid.
On the label
Listed as "gluconolactone" or "glucono delta-lactone" in INCI. Sometimes paired with lactobionic acid — look for either. PHAs are among the few actives where fragile skin can start without a buffer period.
This guide is editorial, not medical advice. For a condition, a reaction or a medical question, see a dermatologist.
On the shelf
Nothing came up for Gluconolactone on the shelf just now. Ask eU; she reads the label first. Or search the shelf yourself.
See also
Glycolic Acid
Alpha-hydroxy acid with the smallest molecular weight of the AHA family, allowing relatively deeper skin penetration.…
Read the guide →Lactic Acid
Alpha-hydroxy acid derived from fermentation. Larger molecule than glycolic acid — gentler exfoliation profile. Also …
Read the guide →Mandelic Acid
Alpha-hydroxy acid with the largest molecular weight of common AHAs — produces the most gradual exfoliation. Particul…
Read the guide →
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